Well. Muslims are pretty family oriented. They usually ask for parent permission to get marry and parent dont usually like a big age difference. Especially if the woman is 22 years older than the guy.
So i am not saying its impossible. You can get marry to anybody (in the opposite sex) but families may not like what you are doing :)
On the other hand, if she is a widow and you are doing it for only good intentions then it maybe ok. But you really need to be in a good economical situation to handle her expenses and keep her happy. Many muslim countries would understand and like marrying a widow to keep her safe. But some (modern muslim countries like Turkey) will get stuck about the age difference.
So that comes down to which muslim are you asking this question to? A Saudi will be very different than a Phillipine.
Hope i could help.